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• When N-CAM and fundamental fibroblast development factor, which is known to stimulate astrocyte division in vitro, have been coinfused into cortical lesion sites, astrocyte proliferation was nonetheless inhibited.
• The pair efficiently fledged chicks, feminine condor #926 and male condor #1048.
• Animals have been lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions.

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Janeczko K. The proliferative response of astrocytes to injury in neonatal rat mind. Janeczko K. The proliferative response of S-100 protein-positive glial cells to damage within the neonatal rat brain. Ssexs O, Edelman GM, Crossin KL. The neural cell adhesion molecule (N-CAM) inhibits proliferation in major cultures of rat astrocytes. The California Condor Recovery Program is a multi-entity effort, led by the us

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We consistently found that the inhabitants of dividing astrocytes was considerably smaller on the facet by which N-CAM or one of many N-CAM-related molecules was infused than on the opposite aspect. The inhibition was best in the cortical lesion websites (approximately 50%) and was less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a significantly smaller inhabitants of dividing astrocytes than the websites on the opposite side.

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